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Moreover, in attempts to replace the hydroxyl group of the tyrosine moiety to avoid potential problems with phase II metabolism compound 27 was prepared (Barlow et al., 2020)

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Future work should move beyond qualitative claims of “biodegradability” toward quantitative degradation kinetics and body-burden profiles in human-relevant models, so that nanocarriers can be compared on the basis of standardized “end-of-life” fingerprints across organs and time scales