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Figure 1 from Adenosyl-L-methionine ( SAMe ) : from the bench to the bedside — molecular basis of a pleiotrophic molecule 1 – 3 | Semantic Scholar

Factors contributing to the suboptimal performance of drugs include the selection of drug targets, the use of biomarkers and animal models in experimental designs, and other issues such as late treatment initiation, dose-dependent side effects, challenges in BBB permeability, and the heterogeneous presentation of patients

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Malhotra, A