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An updated systematic review with meta-analysis for the clinical evidence of silymarin In this review, 65 papers were analysed and confirmed silymarin to have a number of effects, such as anticancer, antidiabetic, and cardioprotective properties

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While the initial mitochondrial oxidant stress seems to be required for Bax translocation [53], Bax does not seem to subsequently influence mitochondrial oxidant stress and peroxynitrite formation, since the protection against APAP-induced liver injury in Bax knockout mice was transient, only occurring at early time points [67]