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Peptides can be designed to include specific biochemical signals (e.g., the RGD cell-adhesion motif or growth factor-binding sequences), endowing these hydrogels intrinsic bioactivity not easily achieved in conventional synthetic polymer gels (Mndlovu et al., 2023[92])

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When this pattern is observed consistently across multiple injections, copper sensitivity is the first thing evaluated and the primary reason protocols are adjusted or discontinued