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GLUTAMATE AND GLUTAMATE RECEPTORS IN NEURODEVELOPMENT Glutamate receptors (GluRs) are expressed very early in development and play a vital role in most aspects of neurodevelopment, including brain wiring, synaptogenesis, progenitor migration, differentiation, and maturation of cells.[55] Activation of NMDARs has been shown to activate specific genes controlling neuronal plasticity and neurodevelopment.[91] NMDARs appear to play a major role in neurodevelopment by its control of Ca 2+ levels, with Ca 2+ gradients being especially critical for cell migrations.[130] Developmental control by NMDARs is directly influenced by their subunit composition