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The test results can be significantly affected by the technique for blood sampling, transport time, and conditions, as well as the analytical method.115 Recent studies indicate, however, that variation in analytical quality of TSB measurements within and between hospitals is acceptable, and does not represent a critical factor in the diagnosis and treatment of jaundiced newborn infants.116 Although it has been shown that TcB correlates relatively well with TSB, the difference between these two measurements can be significant in individual infants109 (Figure 5-4)

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