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First identified in 2012, it is defined by iron-dependent lipid peroxidation and the accumulation of lipid peroxides ( 2.1 Core machinery of ferroptosis The regulation of ferroptosis involves several key components, including GPX4, the cystine/glutamate antiporter system (System Xc-, composed of SLC7A11 and SLC3A2 subunits) and acyl-CoA synthetase long-chain family member 4 (ACSL4) ( Figure 1 )
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23 – 26 Moreover, one of the pseudogenes, ALDH7A1P3 of unknown function, falls within the chromosomal region 7q36, which is strongly associated with autism
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