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For example, unlike the autophagic GPX4 degradation mediated in breast cancer cells by the binding of HSP90 (heat shock protein 90) to GPX4 [71], the upregulation of HSPA5/BIP (heat shock protein family A (Hsp70) member 5) prevents GPX4 degradation through protein-protein interactions in pancreatic cancer cells [77]

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The HisLink™ Protein Purification Resin (Cat.# V8821) overcomes these limitations by using a new modification process for silica surfaces that provides a tetradentate metal-chelated solid support with a high binding capacity and concomitantly eliminates the nonspecific binding that is characteristic of unmodified silica