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The specific issue could be a strong effect on increasing angiogenesis, increased VEGF, increased egr-1 gene, increased NO or eNOS stimulation, and increased free radical formation, interaction with multiple systems, and unescapable risks of unanticipated adverse effects due to pleiotropic effects
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Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer
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