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The CBS (cystathionine beta-synthase) gene catalyses the first step of the transsulfuration pathway, playing a significant role in converting sulfur to sulfate. Mutations in this enzyme may cause excess sulfur in the

AA patients also had increased serum levels of IL-15 compared to controls, and even more in patients with alopecia totalis, a severe form of alopecia areata [63]

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However, treatment with the insulin receptor sensitizer dicholine succinate effectively countered the elevation of TLR4 and alleviated the anxiety and depressive symptoms induced by the high-cholesterol diet (288, 289)