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Four types of inflammasomes have been discovered: NLR family pyrin domain-containing 1 and 3 (NLRP1, 3), NLR family CARD-containing protein 4 (NLRC4), and melanoma-2 (AIM2)

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Hence, it is logical to hypothesize that masking of the terminal –NH 2 group by making a labile chemical derivative of INH, i.e., a derivative which can release INH back when exposed to biofluid in gut or blood (owing to hydrolytic activity of esterase/amidase) can limit known metabolic biotransformations of INH (Figure 6)