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Co-inhibition of glutaminolysis and one-carbon metabolism promotes ROS accumulation leading to enhancement of chemotherapeutic efficacy in anaplastic thyroid cancer | Cell Death & Disease
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum
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Dose-response and pharmacokinetics — Research to characterize absorption, distribution, metabolism, and excretion in reproductive organs, as well as safe dose ranges and optimal delivery routes for focused targeting of gonadal tissue without systemic exposure
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