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Once the integrity of the BTB is lost, dual adverse consequences ensue: on one hand, germ cells in the meiotic or earlier stages lose critical immune shelter, becoming directly exposed to circulating inflammatory mediators and the attacks of infiltrating Th1/Th17 cells and M1 macrophages (5, 24)

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Roosevelt University Hospital, Banska Bystrica, Slovak Republic, 18 Department Of Digestive Diseases Hospital General Universitario Gregorio Marañón Madrid, Spain, 19 Division of Gastroenterology And Hepatology, Montefiore Medical Center, Bronx, NYC, USA, 20 Departamento de Gastroenterología, Hospital San Juan De Dios, Santiago, Chile, 21 Liver Unit, Hospital Vall D’hebron, Universitat Autonoma Barcelona, Ciberehd, Barcelona, Spain., 22 Section of Digestive Diseases, Yale University School Of Medicine/Va-Ct Healthcare System, New Haven, 23 University of Alberta, 24 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Mn, USA Background: Acute kidney injury (AKI) increases mortality amongst patients with alcohol-associated hepatitis (AH)