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CHaC1 upregulation promotes GSH degradation and leads to GSH depletion (Chen M.-S
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Furthermore, direct application of the GIRK activator ML297 failed to completely mimic DAMGO-mediated in vitro OIRD even at concentrations ∼10–100-fold greater than the EC50s for GIRK activation (GIRK1/2, EC 50 = 0.16 μM
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