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Findings from clinical studies also revealed high expression of circulating microRNAs (miRNAs) in the colonic tissues of IBS patients, suggesting the involvement of epigenetic and genetic events in modulating intestinal signaling pathways, particularly serotonin receptor gene with a cis -regulatory variant on the somatic hypersensitivity and intestinal permeability of IBS patients (Kapeller et al., 2008)

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Indeed, Resveratrol is believed to target intracellular signaling pathway components such as regulators of cell survival and apoptosis, pro-inflammatory mediators, and tumor angiogenic and metastatic switches by modulating a distinct set of transcription factors, upstream kinases, and their regulators [53]