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The crystal structure of the “hNNMT-NAM-SAH” ternary complex at 2.7 Å was first determined by Emanuelli using X-ray crystal diffraction
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The analysis of the protocols of cobalamin desensitization and implementation, and the evaluation of the efficacy of this immunotherapy, which has been proposed and tested in clinical conditions by various authors [9,10,11,12,13,14,15,16], leads to the conclusion that cyanocobalamin desensitization is effective and probably leads to long-term desensitization to various cobalamins
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