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Glossary Abbreviations Used 2-DG 2-deoxy-d-glucose ACC acetyl coenzyme A carboxylase ADaM allosteric drug and metabolite AICAR 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside AID autoinhibitory domain AKAP1 A kinase anchor protein ALK5 activin receptor-like kinase-5 AMPK AMP-activated protein kinase CaMKK2 Ca 2+ /calmodulin dependent protein kinase 2 CBM carbohydrate-binding module CBS, cystathionine β-synthase CREB1 cAMP response element binding protein-1 CSC cancer stem cell DDR1 discoidin domain receptor tyrosine kinase 1 DYRK dual-specificity tyrosine-regulated kinase EF2K elongation factor 2 kinase ERK8 extracellular signal-regulated kinase 8 FA fatty acid FAO fatty acid oxidation FLT3 FMS-related receptor tyrosine kinase 3 GBM glioblastoma multiforme GLUT glucose transporter GSC glioblastoma stem-like cells GSK3β glycogen synthase kinase-3β HAP hypoxia-activated prodrug hERG human ether-a-go-go-related gene HIF-1α hypoxia inducible factor 1α HIPK2 homeodomain-interacting protein kinase 2 HMGR 3-hydroxy-3-methylglutaryl-CoA reductase HSC hematopoietic stem cells HTRF homogeneous time-resolved fluorescence IMP inosine monophosphate Lck Lymphocyte-specific kinase LKB1 liver kinase B1 LRRK2 leucine-rich repeat kinase 2 LSC leukemic stem cell MARK3 microtubule affinity-regulating kinase 3 MELK maternal embryonic leucine zipper kinase MET mesenchymal-epithelial transition factor MLK1 mixed lineage kinase 1 MNK1 MAP kinase-interacting kinase 1 MSK1 mitogen- and stress-activated protein kinase 1 MST3 mammalian STE20-like protein kinase 3 mTORC mammalian target of rapamycin complex NRF2 nuclear factor erythroid 2-related factor 2 NUAK1 NUAK family SNF1-like kinase 1 PAK1 P21 (RAC1) activated kinase 1 PDGFR platelet-derived growth factor PD-L1 programmed cell death ligand 1 PFK1 phosphofructokinase 1 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 PHK phosphorylase kinase PI3K phosphoinositide 3 kinase PP2C protein phosphatase 2C PRN1 serine/threonine-protein kinase N1 PTEN phosphatase and tensin homologue ROR2 receptor tyrosine kinase-like orphan receptor 2 ROS reactive oxygen species RSK 90 kDa ribosomal S6 kinase RTK receptor tyrosine kinase TAK1 TGF-β activating kinase 1 T-ALL T-cell acute lymphoblastic leukemia/lymphoma TBC1D1 TBC1 Domain Family Member 1 TME tumor microenvironment TOR target of rapamycin TSC2 tuberous sclerosis complex 2 TXNIP13 thioredoxin-interacting protein ULK1 unc-51-like kinase 1 VEGFR vascular endothelial growth factor receptor YAP yes-associated protein Biographies Juliet E