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Being a potential potent inhibitor of LRRK2 kinase activity with low risk for off-target side effects, Vit B12 supplementation in patients with PD (PwPD) seems appealing and encourages future clinical trials to investigate this potent effect as such evidence remains restrained to animal models (Green and Christine 2019) (Fig

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This water-soluble vitamin is absorbed in the stomach but requires the help of a certain protein, known as the intrinsic factor that binds with vitamin B12, for the blood and cells to absorb it