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however, in phase 1 clinical trial, BIIB078 failed to exert meaningful effects on CNS pathologies and had no significant impact on neurofilament levels but paradoxically increased inflammatory marker CCL26, and its development has been discontinued (van den Berg et al., 2024

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It is classified as a conditionally essential amino acid, meaning that while the body can typically synthesize it on its own, there are circumstances, such as intense physical activity, illness, or injury, that may increase the demand for glutamine and necessitate dietary supplementation

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